Diabetes mellitus is a group of autoimmune diseases characterized by defects in insulin secretion resulting in hyperglycemia (an abnormally high concentration of glucose in the blood). Over time, diabetes can lead to blindness, kidney failure, nerve damage, hardening of the arteries, and death. The disease is the third leading cause of death in the United States after heart disease and cancer.
A search of the scientific literature reveals no clinical investigations of cannabis for the treatment of diabetes, but does identify a small number of preclinical studies indicating that cannabinoids may modify the disease’s progression and provide symptomatic relief to those suffering from it.
Most recently, a study published in the journal Autoimmunity reported that injections of 5 mg per day of the non-psychoactive cannabinoid CBD significantly reduced the incidence of diabetes in mice. Investigators reported that 86% of untreated control mice in the study developed diabetes. By contrast, only 30% of CBDtreated mice developed the disease.[3] In a separate experiment, investigators reported that control mice all developed diabetes at a median of 17 weeks (range 15-20 weeks), while a majority (60 percent) of CBD-treated mice remained diabetes-free at 26 weeks.
A 2001 trial demonstrated that delta-9-THC could moderate an animal model of the disease by reducing artificially-elevated glucose levels and insulitis in mice compared to non-treated controls.[8]
With the incidence of diabetes steadily increasing in both the adult and juvenile population, it would appear that further cannabinoid research is warranted in the treatment of these diseases.
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